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Specifically, IFN- activates macrophages, neutrophils, and dendritic cells (DC) to destroy intracellular pathogens by producing reactive oxygen species (ROS), reactive nitrogen species, and antimicrobial peptides

At 48 weeks with the 12mg dose: systolic blood pressure dropped 7.4 mmHg, triglycerides fell 30%, HDL cholesterol increased 8%, and HbA1c decreased 0.4% even in participants without diabetes

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Talimogene laherparepvec improves durable response rate in patients with advanced melanoma