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The reduced ability to perform daily tasks (for example, showering or preparing food) results in difficulties maintaining a job or attending school and participating in social activities [16]

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COX-2 selective NSAIDs (i.e., COX-2 inhibitors or coxibs) inhibit COX-2 more strongly than COX-1, resulting in less gastrointestinal side effects, but potential cardiovascular complications, most notably an increase in the risk of heart attack due to increased blood clotting propensity (see below) (Conaghan 2012)

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