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In the case of TQ, additional preclinical investigations are needed to assess the pharmacokinetics, biodistribution, and toxicity profiles of various nano-TQ formulations

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Baseline cohort definitions include demographic characteristics (e.g., age, sex, race/ethnicity, diabetes duration, smoking rate), relevant biomarkers (e.g., HbA1c, systolic and diastolic blood pressure, total cholesterol, low- and high-density lipoprotein, triglycerides, BMI, heart rate, white blood cell count, and estimated glomerular filtration rate), and history of micro- and macrovascular complications (e.g., eye disease, diseases of the lower extremities, kidney disease, heart disease, heart attack, heart failure, and stroke)