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An Evidence-Based Perspective. DrLewis.com, Jan 4, 2026

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Statins induce both mitochondrial oxidative stress and calcium-dependent permeability transition, which may lead to cell injury and death

Mitophagy and DPN Silymarin (SBN), a sirtuin 1 activator, ameliorated sciatic nerve injury and oxidative damage in HG-induced mouse neuroblastoma cells (N2A) and STZ-induced SD rats and enhanced autophagy and mitophagy, which exerted some neuroprotective effects [167]