Within the NHS, medications like Wegovy are typically prescribed through specialist weight management services and usually for up to 2 years
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Advancements in bioavailability technologies, formulation stability, shelf-life enhancement, and storage optimization are also expanding accessibility across emerging markets with limited cold-chain infrastructure
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Animal experiments have demonstrated that high-fat diet downregulates tight junction protein expression (such as occludin and ZO-1), reduces mucus layer thickness, and increases intestinal permeability (89)
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