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Expression of these thyroid antigens in the fetal thymus is under control of the AIRE gene, and absence of this gene leads to polyglandular autoimmune syndrome type 1 whose hallmarks are adrenal insufficiency, hypoparathyroidism and muco-candidiasis

Klopstock TF, Tricta L, Neumayr, et al

As the disease progresses, hypoxia may induce the release of angiogenic inflammatory cytokines (i.e

The reduction of cytochromec by milk xanthine oxidase

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