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J Immunol 1985

Diana T, Olivo PD, Kahaly GJ

To evaluate its performance, a phase II clinical trial was conducted with 293 patients with a weekly dose of 2.4, 4.8, or 6.0 mg, versus placebo

Sensitivity analyses were performed by omitting eligible trials one by one

Tendinopathy causes a decrease in collagen in the injured tendon, but it actually causes an increase in proteoglycans and GAGs, such as chondroitin sulfate and hyaluronan.[7,8,13,18,40] Gluscosamine sulfate and chondroitin sulfate might help build proteoglycans, but since the levels of GAGs and proteoglycans are already abnormally high in tendinopathy, you wouldn't expect oral supplementation of glucosamine and chondroitin to help

This figure shows a regional plot for the BMI, maximum, inv-normal transformed phenotype