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Safety data is similarly limited, with the tolerability of creams and long-term effects sparsely analyzed in the literature

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In male Wistar rats experiencing transient ischemic stroke, UA suppresses the upregulation of cerebrocortical Vegfa expression in the acute phase of stroke and reduces the MMP-9/TIMP-1 ratio in the brain cortex, indicating that UA treatment may aid in the downregulation of the VEGF-A/MMP-9 pathway to improve BBB integrity [54]

Similarly, the expression levels of these proteins followed the same trend in co-cultured MCECs (Figures 6EH)

To determine whether dysregulated hepatic glutathione homeostasis and TNF can synergistically contribute to hepatocyte death, we performed cell culture studies using both human hepatoma cells and mouse non-transformed hepatocytes