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S5E), although analysis of hepatocellular injury and serum AST and ALT levels showed a significant increase compared to Gclc WT mice (Fig

Most patients reach a therapeutic dose between 1.0 mg and 2.4 mg within 1216 weeks using a standard titration schedule, though timelines vary based on individual tolerance

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For example, insulin levels and hemoglobin A1C, which is a measure of glucose control, worsens [and] lipid profile components like total cholesterol, triglycerides, and low-density lipoprotein increase