If you want the biology the literature predicts, you need a delivery method that bypasses the stratum corneum
SCFAs activate the GPR43 pathway to stimulate potassium efflux and hyperpolarization, consequently resulting in the activation of NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome, which keeps the integrity of the intestinal barrier through reparation and cell survival under stress conditions (Li et al., 2024)
Despite this accumulating evidence, paracetamol (PAC) was suggested as a safer and recommendable alternative for the early and domiciliary management of pain and fever in COVID-19 patients
The effect of collagen I mimetic peptides on mesenchymal stem cell adhesion and differentiation, and on bone formation at hydroxyapatite surfaces
Nature 424 , 901908 (2003)
Also referenced as Wolverine Stack , it is frequently used in laboratory models examining repair signaling and cell migration models and cellular response mechanisms