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Subsequent debate regarding assay specificity, circulating concentrations, and translational relevance led to skepticism regarding irisins role in humans

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It is this nuanced interaction among bodily functions that enables such pharmaceuticals to furnish outcomes surpassing mere glucose level adjustments

In agreement with the results of Tang, no changes in liver fat content and surrogate biomarkers of fibrosis were shown in a RCT comparing the effect of a 12-week course with liraglutide versus sitagliptin or placebo among 52 overweight diabetic patients on metformin or sulphanylurea

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