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In FDA forehead-line trials, headache was reported in 9% of BOTOX Cosmetic participants versus 5% receiving placebo

It has accelerated healing of transected tendons and ligaments in rats when given by several routes, improved muscle and bone-to-tendon junction recovery, and protected gut tissue in ulcer and colitis models

Increased Incidence and Risk of Hair Loss with GLP-1 Receptor Agonists: A Real-World Multicenter TrinetX Cohort Study

No adequate animal-reproduction or controlled-human studies have been conducted to evaluate teratogenicity or developmental toxicity

Slika et al

Conversely, the expression of CB2 within the CNS is minimal but has been detected under certain pathological conditions including nerve injury and inflammation