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SURMOUNT-5: The head-to-head trial Published in the New England Journal of Medicine in 2025, SURMOUNT-5 was the first randomised trial to directly compare tirzepatide (Mounjaro) with semaglutide (Wegovy) at equivalent maximum doses in adults with obesity without type 2 diabetes

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Medication can help appetite signals, but habits drive long-term results

However, serum alkaline aminotransferase, total cholesterol triglycerides, albumin, and high density remained unchanged in all animals following therapeutic and supra-therapeutic administrations

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