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It is good to teach patients what the potential side effects might be, and help them understand the sense of fullness

References: Once-Monthly Maridebart Cafraglutide for the Treatment of Obesity A Phase 2 Trial

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But berberine is still a reasonable option for some people looking for gentle, natural metabolic support, and that is a different goal from prescription weight loss

GLP-1s are contraindicated in individuals with a history of medullary thyroid carcinoma, a family history of such, or in patients with multiple endocrine neoplasia syndrome type 2