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To confirm that GPX4 is a senolytic target, we took advantage of three widely used GPX4 inhibitors: FIN-56, ML-210 and RSL3 42

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PubMed Gruchlik A, et al

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The secretions of TNF and IL-6, the priming agents regulating the entry into G1 phase, were delayed leading to a postponed induction of the immediate-early genes such as c-Fos and Jun-B as well as a late and reduced activation of STAT3