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long-term safety data still accumulating
Some report that lower doses, including approaches like low-dose semaglutide or semaglutide microdosing, feel easier to tolerate and less disruptive to daily routines, particularly early in treatment
BMI can over and underestimate body fat [archived link] since it doesnt distinguish fat from bone and muscle mass
*Results may vary
However, no direct head-to-head comparisons have been conducted, and the 48-week timeframe in the retatrutide trial is shorter than the 6872 week endpoints used in the semaglutide and tirzepatide phase 3 trials, making direct numerical comparison imprecise
For example, GLP-1 medications are large protein molecules, and most experts believe theyre unlikely to transfer into breast milk in significant concentrations
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