In comorbid patients, dysbiosis upregulates SERT expression and impairs EC cell function, reducing colonic 5-HT content ( Carriers of the short allele of the SERT gene polymorphism (5-HTTLPR) show lower transporter activity and greater susceptibility to comorbid phenotypes ( 4.1.2 The GABA pathway Beyond the 5-HT system, GABA, as the most abundant inhibitory neurotransmitter in the CNS, has a core role in mood regulation and anxiety control
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For patients considering semaglutide, understanding your unique metabolic profile and GLP-1 receptor sensitivity can help set appropriate expectations
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