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Skeletal muscle can release medium-chain acylcarnitines (MCACs) into the circulation to remove acyl-CoA, which can be detrimental to cellular function, particularly when the supply of energy substrates exceeds the oxidative capacity of the TCA cycle

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Were seeing ongoing trials, where theyre trying multiple mechanisms of action, and multiple combinations with different types of muscle atrophy drugs to make these even more effective at reducing fat, MacDonald says

As treatment extends beyond three years, clinicians must consider how gastrointestinal tolerability evolves over time

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