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Glutamine-addicted cells exhibit a decreased survival, or even undergo apoptotic cell death, associated with an increased in DNA damage, an overproduction of ROS or a decreased reduced/oxidized glutathione (GSH/GSSG) ratio

Revised criteria, designed to trigger diagnostic testing, were published based on the frequency of criteria in molecularly proven individuals 2 (Table 2)

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Note: If you choose to use both, start one at a time