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In Vivo wild-type mice under dietary methionine restriction [1]

In addition to blunted monoaminergic neurotransmission, it was also shown that deficiency in neurotrophic factor effects, disturbances in neurogenesis and synaptogenesis, chronic neuroinflammatory processes, and dysregulation of the hypothalamicpituitaryadrenal (HPA) axis can largely contribute to the manifestation of depressive symptoms in patients [3,4,5]

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Cox AD, Der CJ

doi: 10.1056/NEJMoa022050 37 YangZTaoYX