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Considerations: Exceeding daily doses of vitamin B12 beyond 10 mcg may induce a hematologic response in patients with folate deficiency

Xing X, Dan Y, Xu Z, Xiang L

The majority of the cases (84.5%) involved hepatitis C infection, which may have made conclusions less applicable to cases of chronic liver disease secondary to other etiologies

B-12 injections are quick and tolerable

The safety data for each compound individually is reassuring, but combination safety requires its own evaluation because pharmacological interactions can produce unexpected results even when each agent is well-characterized on its own

Digested samples were desalted using a C18 spin column (Pierce C18 Spin, #89873) according to manufacturer instructions prior to resuspension in EPPS buffer and CH 3 CN for TMT labeling as described above