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In addition to activation by NAPQI, the Nrf2 signalling pathway is also regulated by protein tyrosine phosphatase 1B (PTP1B) and M1 muscarinic receptors (M1Rs) (Mobasher et al., 2013

doi: 10.1016/j.neubiorev.2015.04.015

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Synovium hyperplasia is a key factor in the development of RA, which contributes to cartilage degradation and invasive pannus formation (131)

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