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A study from Li et al

Additionally, GLP-1 receptors are expressed in parts of the brain involved in mood and the reward system, which could explain the reductions we observed in alcohol and substance use. These benefits appeared especially pronounced in psoriasis patients compared with matched controls, suggesting a possible synergy between systemic inflammation in psoriasis and the mechanisms of GLP-1 RAs

You might not feel a major difference after one night, but many people notice changes in their energy and skin clarity after 4 to 8 weeks of consistent use