microdosing tirzepatide protocol I'm starting a new longevity protocol: Tirzepatide, a dual GLP-1/GIP receptor agonist. Here is the existing evidence, my protocol, measurement plan, and what I expect to achieve by this intervention. 🧵 Tirzepatide dosage chart for weight

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NTS GLP-1R neurons, sensitive to nutritive stimuli, induced satiety without aversion, whereas AP GLP-1R neurons elicited strong nausea-like behavior in mice

The reason is clear: HRT improves the hormonal foundation Low estrogen contributes to insulin resistance, increased belly fat, and a decline in lean muscle mass

Side effect limited responders The medication might have worked if you could have tolerated it

Though GLP-1 monomers are roughly 4 kDa, dimers (8-10 kDa) and higher-order oligomers can form