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TNF-, another key cytokine elevated in PCOS, sustains this activation loop by upregulating endothelial adhesion molecules (ICAM-1, VCAM-1, and E-selectin), thereby enhancing neutrophil tethering and transmigration

In the liver, although both increased FFA uptake and upregulated de novo lipogenesis contribute to the development of hepatic steatosis, accumulating evidence suggests that increased FFA uptake plays a predominant role in the development of fatty livers 1

Supplementary Data 4 (download XLSX Statistical source data for Supplementary Fig

Several studies demonstrated that combination therapy with hydroquinone, tretinoin and topical steroids is more effective, reliable, and safer in treatment of melasma as compared with hydroquinone alone and it provides rapid and sustained clinical improvement in the treatment of melasma

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