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A referral to a geneticist is suggested to confirm the diagnosis.75 See Appendix 3 for more information on setmelanotide in certain rare forms of monogenic obesity

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[4] [6] Beyond their well-established effects on glucose metabolism and appetite regulation, GLP-1 receptor agonists exert multiple cardiovascular effects

While several gut hormones secreted by intestinal enteroendocrine cells may contribute to the gut-kidney axis, studies have shown that an oral sodium load can increase endogenous GLP-1 concentrations (18)

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