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doi: 10.1093/jexbot/53.372.1283 45 NoctorG.MhamdiA.ChaouchS.HanY.NeukermansJ.Marquez-GarciaB.et al

Gene Activation: MC1R activation initiates a signaling cascade (cAMP production $\rightarrow$ MITF expression) that induces the enzymes (tyrosinase) necessary for eumelanin production

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Because the acetyl group enables the molecule to cross the blood-brain barrier more easily and may also provide substrate (acetyl groups) for synthesis of acetylcholine-a primary neurotransmitter in the brain

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