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In TRIUMPH-3, retatrutide meaningfully reduced certain cardiovascular risk factors, with the highest dose delivering average reductions of 37.0% in triglycerides, 16.5% in non-HDL cholesterol, 9.3 mmHg in systolic blood pressure, 7.5 in (19.0 cm) in waist circumference, and 51.2% in high-sensitivity C-reactive protein (hsCRP)
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Phase 3 clinical trials collectively referred to as the TRIUMPH programme are now underway internationally, evaluating retatrutide across broader populations including individuals with type 2 diabetes, obesity-related cardiovascular disease, and metabolic dysfunction-associated steatohepatitis (MASH, formerly known as NASH)
At launch, the pill isn't available on the NHS
The Reality Check While the efficacy is impressive, we need to discuss tolerability
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