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In laboratory animals, the forced overexpression of the TKT gene promotes the development of MAFLD as well as the advancement of MAFLD to the more severe state referred to as metabolic dysfunction-associated steatohepatitis (MASH)

Nevertheless, because of the geometry chosen, restriction to a 2D model for the epidermis and a continuous flux of incoming nutrient, the concentration may diverge in the simulation

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Hope DCD, Hinds CE, Lopes T, Vincent ML, Shrewsbury JV, Yu ATC, et al