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When a needle pierces the skin, even a very thin one like the needle used for Wegovy, these receptors send a signal to your brain that something is happening

Thats why planning ahead with supportive nutrition, activity, and behavioral strategies matters so much as you start transitioning off therapy

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In turn, this prevents oxidative metabolism of pyruvate to acetyl-CoA and hinders the ATP supply to skeletal muscle (Hargreaves and Spriet 2020)