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doi: 10.1016/S1474-4422(07)70104-7, PMID: [DOI] [PubMed] [Google Scholar] 30

These promoter regions act like dimmer switches for gene expression, and by binding here, Epitalon appears to gently dial up telomerase gene transcription without altering the DNA itself

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A biomarker effect without a clinical one, as seen in EVOKE, is exactly the dissociation that should make researchers cautious about surrogate measures

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