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In adults, neurologic symptoms of biotin deficiency include depression, lethargy, hallucinations, and numbness and tingling of the extremities (35)

So these are studies that are genome-wide associated studies

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Nasal delivery avoids injection site risks (infection, bruising, irritation) but introduces nasal mucosal irritation and formulation stability concerns

Last reviewed: June 15, 2026 Last updated: June 15, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations