Both can be used temporarily, though loperamide should not exceed 8 mg per day without medical guidance
doi: 10.1016/s0014-2999(99)00486-0
This regulation was shown to occur under the direct transcriptional control of GA-binding protein alpha (GABPA)a critical Ets-family transcription factor that acts as a master regulator of mitochondrial biogenesis by controlling the expression of nuclear-encoded mitochondrial proteins, and whose direct binding to the PHB2 promoter makes it a key upstream determinant of the cells capacity for mitophagy (60)
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Zahir, H., Greenberg, J., Hsu, C., Watanabe, K., Makino, C., He, L
How -Glu-Tau exerts such functions largely remains ambiguous, however, partly because the target receptor molecules remain unidentified [158]