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This D-amino acid substitution introduces conformational rigidity within the pharmacophore core (His-D-Phe-Arg-Trp) and significantly increases binding affinity across melanocortin receptor subtypes compared to both -MSH and MT-1

This unexpected link between mitochondrial glutathione and m -AAA protease AFG3L2 might lead to new pathophysiological mechanisms under a diverse clinical spectrum of AFG3L2 mutation-associated neurodegenerative disorders that range from ataxia to parkinsonism 29,43

In addition to these in vitro findings, an ex vivo study was conducted using an ethanolic extract derived from the aerial parts (leaves and stems) of Cineraria maritima , applied to a goat lens cataract model induced by sodium selenite

10.1042/BST0360343 83

M.Rodriguez-PalaciosA

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