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The most common side effect is minor, temporary redness or discomfort at the injection site

Safety Profile and Potential Concerns While both compounds generally exhibit favorable safety profiles, important distinctions exist in their risk-benefit considerations

Keeping medication in a visible location in the refrigerator where it is encountered regularly serves as a visual reminder

ATTAIN 1 clinical trial demonstrates that individuals with overweight and obesity who used the highest dose of orforglipron (36 mg) lost 12.4% of body weight after 72 weeks

In contrast, orforglipron lasts for up to two days, and semaglutide lasts for a full week